克矽平(Polyvinilpyridine-N-Oxide)是一种高分子聚合物,具有保护巨噬细胞,防治实验性矽肺的作用。经临床试用证实毒性低使用安全,对矽肺病变有一定疗效。虽然人们对它的作用机理进行了大量实验研究和临床观察,但有关支气管肺冲洗细胞和超微结构的报导尚少见。为此,我们利用大鼠作一次气管染尘,定期解剖的方法,获取支气管肺冲洗细胞进行细胞计数,并利用扫描和透射电镜观察石英微粒对巨噬细胞的毒性和克矽平对细胞超微结构的保护作用。 Polyvinilpyridine-N-Oxide is a kind of macromolecule polymer with the function of protecting macrophages and preventing experimental silicosis. Clinical trial confirmed that the low toxicity of safe use of silicosis have a certain effect. Although a large number of experimental and clinical observations have been made on its mechanism of action, reports on bronchoalveolar lavage cells and ultrastructure are rare. To this end, we used a rat trachea for dust, regular dissection method to obtain bronchoalveolar lavage cells for cell count, and the use of scanning and transmission electron microscopy of quartz particles on macrophage toxicity and grams of sildenafil on cell ultrastructure Structure protection.