小窝蛋白-1、基质金属蛋白酶-2在膀胱癌的表达及其关系

来源 :中德临床肿瘤学杂志(英文版) | 被引量 : 0次 | 上传用户:zabdtt
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase-2 (MMP-2) in bladder cancer and its clinical significance. Methods: The expression of CAV-1 and MMP-2 were detected by the SP immunohistochemical method in 77 cases of bladder cancer. Results: The positive rates of CAV-1, MMP-2 in bladder transitional cell carcinoma (BTCC) and bladder adenocarcinoma were significantly high than those of normal bladder mucosa, the positive rates in the deeper cancer invasion was significantly high than those of superficial bladder cancer (P < 0.01), the positive rates of CAV-1 in grades Ⅰ, Ⅱ and Ⅲ of bladder transitional cell carcinaoma (BTCC) were 15%, 40% and 68%, respectively;the positive rates of MMP-2 in grades Ⅰ, Ⅱ and Ⅲ of bladder transitional cell carcinoma (BTCC) were 20%, 40% and 72%,respectively (P < 0.01). CAV-1 was positive associated with MMP-2 in bladder cancer (r= 0.598, P < 0.001), but not in bladder tissue. Conclusion: CAV-1 and MMP-2 were associated with stage and grade of bladder cancer, which suggested that CAV-1might improve secretion of MMP-2.
其他文献
上三年级的女儿放学回家后饭量大减,有时只是象征性地扒拉两口饭。我开始在菜单上做文章,失望的是,女儿连过去最喜欢吃的鸡蛋卷也只吃了一个。与同事们聊到这件事。同事孟姐
语文基础知识的教与学一直是语文教学的重点和难点,尤其是在当前基础教育课程改革新形势下,能够让学生在愉悦、轻松的学习氛围中掌握好语文基础知识,从而提高综合运用语言的能力
内部控制在公立医院管理中起着重要作用,但是目前我国医院内部控制还不够健全,本文论述了内部控制在医院管理中存在的问题,并对解决对策给出了抛砖引玉的建议.
目的:观察中西医结合治疗肺心病急性加重期的临床疗效.方法:将70例纳入观察的患者随机分为治疗组和对照组各35例.对照组采用西医常规治疗,治疗组在对照组治疗基础上自拟祛痰
我国刑法第三百九十九条规定了徇私枉法罪的犯罪构成要件及其刑罚,其中,在主观要素的描述中,将徇情枉法与徇私枉法置于并列的关系。但是,这种并列关系是否成立?如果不是并列
Objective: To study the expression of connexin43 (Cx43) gene and its correlation with the apoptosis related genes Bcl-2 and Bax in transitional cell carcinoma o
前科即犯罪记录,是指对既往犯罪的一种客观事实记载。作为一项基本刑罚制度,前科被世界上大多数国家或者地区的刑法所采用。前科的影响力在我国刑事法律和民事行政法律中都有
本文通过对荣华二采区10
作为社会主义道德体系重要部分的职业道德,在教育工作者的工作中主要体现培养“四有”新人.培养“四有”新人,要以有理想为核心内容.