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目的探讨丹参注射液对肠缺血再灌注损伤的保护机制及临床意义。方法将120例急性肠道缺血性疾病患儿随机分为丹参治疗组与常规治疗组,对术后不同时期患儿血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、丙二醛(MDA)、分泌型免疫球蛋白A(sIgA)、T淋巴细胞亚群(CD4+、CD8+)的含量进行分析,观察住院时间及肠功能恢复率。结果有效剂量的丹参治疗组血清TNF-α、IL-6、MDA含量显著低于常规治疗组;而血清sIgA、CD4+含量及CD4+/CD8+比值明显高于常规治疗组,住院时间缩短、肠功能恢复率升高,差异有统计学意义。结论丹参注射液能够减轻肠道缺血再灌注损伤,有效保护肠道黏膜屏障,调节体液及细胞免疫功能,对肠道缺血性疾病有明显的保护作用。
Objective To explore the protective mechanism and clinical significance of Salvia miltiorrhiza on intestinal ischemia-reperfusion injury. Methods 120 children with acute intestinal ischemia were randomly divided into three groups: the Salvia miltiorrhiza group and the conventional treatment group. The levels of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) ), Malondialdehyde (MDA), secreted immunoglobulin A (sIgA) and T lymphocyte subsets (CD4 +, CD8 +) were measured. The length of hospital stay and recovery of intestinal function were observed. Results The serum levels of TNF-α, IL-6 and MDA in the Salvia miltiorrhiza group were significantly lower than those in the conventional treatment group. The serum levels of sIgA, CD4 + and CD4 + / CD8 + were significantly higher than those in the conventional treatment group Rate increased, the difference was statistically significant. Conclusion Salvia miltiorrhiza injection can reduce intestinal ischemia-reperfusion injury, effectively protect the intestinal mucosal barrier, regulate humoral and cellular immune function, and have obvious protective effect on intestinal ischemic disease.