长期以来,人们普遍认为暴露在寄生虫表面的抗原是保护性免疫反应重要的靶。但是显而易见,血吸虫的保护性抗原并非都是表面抗原,也不是所有表面抗原都是保护性免疫的靶。作者提出,决定表面抗原免疫学功能的因素之一可能是不同发育阶段的表达。 For a long time, it is generally accepted that antigens exposed on the surface of parasites are important targets of protective immune responses. However, it is clear that not all of the protective antigens of schistosomes are surface antigens, nor are all surface antigens the targets of protective immunity. The authors suggest that one of the factors determining the immunological function of surface antigens may be the expression at different developmental stages.