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从70年代起,核酸碱基的光环合加成反应引起了一些学者的兴趣,氮杂嘧啶碱基的光环合加成研究也正逐步深入。1,2,4-三嗪-3,5-二酮(6-氮杂脲嘧啶)为抑菌剂并具有一定的抗癌作用。我们利用1,2,4-三嗪-3,5-二酮中的碳氮双键与烯烃的碳碳双键进行光环合加成反应,得到一系列带有氮杂环丁烷的新化合物,并发现这种反应具有很好的区域选择性。本文利用~1H、~(13)C和~(15)N核磁共振对1,2,4-三嗪-3,5-二酮及其衍生物进行了较系统的结构鉴定和分析,并探讨了不同取代基的电子效应对衍生物化学位移的影响。
Since the 1970s, the photocyclic addition reaction of nucleic acid bases has aroused the interest of some scholars. The study on the photocyclic addition of azapyrimidine bases is also going deeper and deeper. 1,2,4-triazine-3,5-dione (6-AZA) is a bacteriostatic agent and has some anti-cancer effects. We use 1,2,4-triazine-3,5-dione carbon-nitrogen double bond and olefin carbon-carbon double bond photocyclisation reaction to give a series of azo compounds with azetidine , And found that this reaction has good regioselectivity. In this paper, 1,2,4-triazine-3,5-dione and its derivatives were systematically identified and analyzed by ~ 1H, ~ (13) C and ~ (15) N NMR. Effect of Electronic Effects of Different Substituents on Chemical Shift of Derivatives.