在逐步放大试验和钨装载量模拟试验的基础上，成功地制备了数个居里级的１８８Ｗ－１８８Ｒｅ发生器，１８８Ｗ的最大装载量达４０．７ＧＢｑ。１８８Ｒｅ的淋洗效率为９０％（１０ｍＬ淋洗体积），１８８Ｗ的漏穿为４×１０－７，得到的无载体的１８８Ｒｅ洗脱液核纯度＞９９．９％，放化纯度大于９９％， ｐＨ值为５，铝含量～１μｇ／ｍＬ，无菌、无热原符合药典要求，可用于制备各种１８８Ｒｅ标记的放射性治疗药物。 Based on the gradual enlargement of the test and the simulation of tungsten loading, several Curie 188W-188Re generators were successfully prepared. The maximum load of 188W was 40.7GBq. The 188Re elution efficiency was 90% (10 mL rinse volume) and 188 W leakage was 4 x 10-7. The resulting carrier-free 188 Re eluate had a purity of> 99.9% and a radiochemical purity of> 99% pH value of 5, aluminum content ~ 1μg / mL, sterile, pyrogen free complies with Pharmacopoeia requirements, can be used for the preparation of a variety of 188Re labeled radiopharmaceuticals.