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目的分析外周性原始神经外胚瘤(pPNET)病人CE(卡铂、足叶乙甙)方案化疗后的近期疗效观察及毒副作用,探索CE方案治疗pPNET的可行性。方法对6例pPNET病人的治疗方式、化疗周期、疗效及生存期进行评价。结果可评价疗效4例,其中局部复发及Ⅳ期病人各1例,6个周期后CR;1例Ⅳ期病人4个周期后PR;1例原发于胸腰椎病人2个周期后SD;其余2例为辅助化疗。仅出现1次Ⅲ度骨髓抑制,胃肠道反应最重Ⅱ度,未见其他不良反应。结论 CE方案可在部分pPNET病人化疗时应用,对改善远期生存状况的影响尚需进一步验证。
Objective To analyze the short-term efficacy and side effects of CE (carboplatin, etoposide) chemotherapy in patients with peripheral primitive neuroectodermal (pPNET) and explore the feasibility of using the CE regimen in the treatment of pPNET. Methods Six patients with pPNET were evaluated on the treatment, chemotherapy cycle, efficacy and survival. Results Four patients with local recurrence and one with stage Ⅳ disease, one with stage 6 disease, one stage with stage 4 disease after 4 cycles of PR, one case with primary outcome after 2 cycles with thoracolumbar disease, and the remaining 2 cases of adjuvant chemotherapy. Only one degree Ⅲ myelosuppression appeared, the degree of gastrointestinal reaction was the second degree, and no other adverse reactions were found. Conclusions The CE regimen can be used in chemotherapy of some patients with pPNET, which needs to be further verified to improve the long-term survival status.