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目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者咽组织中P物质 (SP)、血管活性肠肽 (VIP)的含量与咽腔狭窄的关系。方法 :对 30例OSAS患者用半定量方法检测咽组织中SP和VIP的含量并与 12例健康成人的咽组织进行对照。结果 :OSAS患者咽组织中的粘膜上皮层、小血管内皮层、平滑肌周围、腺泡及腺导管周围 ,均有SP、VIP分布 ;其含量与对照组比较明显增加。结论 :咽部SP、VIP增多引起咽组织肿胀加重 ,OSAS患者咽腔狭窄 ,提示神经源性炎症是参与OSAS发病的重要因素之一。
Objective: To investigate the relationship between the contents of substance P (SP) and vasoactive intestinal peptide (VIP) in pharyngeal stenosis in patients with obstructive sleep apnea syndrome (OSAS). Methods: The contents of SP and VIP in pharyngeal tissues were detected by semi-quantitative method in 30 OSAS patients and compared with the pharyngeal tissues of 12 healthy adults. Results: There were SP and VIP distribution in the mucosa, small endothelium, smooth muscle, acinar and glandular ducts of pharyngeal tissues of OSAS patients. The contents of SP and VIP were significantly increased in OSAS patients. Conclusion: Increased pharyngeal SP and VIP cause swollen swollen pharyngeal tissues and narrow pharyngeal cavity in OSAS patients, suggesting that neurogenic inflammation is one of the important factors involved in the pathogenesis of OSAS.