论文部分内容阅读
目的:了解海拔4 250m地区高原人群血清EPO(红细胞生长素)、T(睾酮)、E2(雌二醇)含量变化与HAPC(高原红细胞增多症High AltitudePolycythemia,HAPC)的相关关系。方法:在海拔4 250m地区筛选出HAPC,且测定了世居高原藏族、移居高原汉族、高原红细胞增多症患者三组人群血清中EPO、T、E2含量。结果:HAPC组:移居高原汉族18人(占66.66%),世居高原藏族9人(占33.33%),男女比例为26:1,三组间EPO差别无显著性,P>0.05,但是高原人群血清中的EPO含量高于平原地区3.788倍。三组间T、E2差别无显著性,P>0.05,T在高原红细胞增多症、世居高原藏族和移居高原汉族三组间差别无明显性,但是T低于平原地区8.43倍。可能与高原人群T的活性增加有关,在今后的工作做进一步调查。结论:EPO、T、E2与HAPC的发病虽然无直接因果关系,但是EPO含量高于平原人群3.788倍,T含量明显低于平原人群8.43倍,EPO的增高和T的降低是一种高原人群的生理病理特征表现。
Objective: To investigate the relationship between serum EPO (erythropoietin), T (testosterone), E2 (estradiol) and HAPC (High Altitude Polycythemia, HAPC) in the plateau at an altitude of 4 250m. Methods: HAPC was screened at 4 250 m above sea level. The levels of EPO, T and E2 in sera of three groups of people living in plateau, emigrant plateau Han nationality and plateau polycythemia were measured. Results: In the HAPC group, there were 18 Han Chinese (66.66%) and 9 Tibetan native (33.33%) in the Himalayan Plateau, with a ratio of 26: 1. There was no significant difference in EPO between the three groups (P> 0.05) EPO content in human serum is 3.788 times higher than that in plain area. There was no significant difference in T and E2 between the three groups (P> 0.05). There was no significant difference between the three groups in Tibetan Plateau and Plateau Hemophilia, but the T was 8.43 times lower than that in Plain Plateau. May be related to the increased activity of T in the plateau population and further investigation will be conducted in future work. Conclusions: Although there is no direct causal relationship between EPO, T, E2 and HAPC, EPO content is 3.788 times higher than that of plain people and T content is 8.43 times lower than that of plain people. The increase of EPO and the decrease of T are a high altitude group Physiological and pathological features.