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目的分析潍坊市2012年疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,评价AEFI监测系统运转情况及预防接种安全性。方法采用描述性流行病学方法对潍坊市2012年1月1日至12月31日报告的AEFI个案数据进行分析。结果 2012年潍坊市合计报告AEFI 1 012例,报告发生率为36.76/10万。报告发生率,一般反应为36.10/10万,异常反应为0.51/10万,偶合症为0.07/10万,心因性反应为0.04/10万;百白破(无细胞)疫苗为109.84/10万,流脑A+C结合疫苗为83.50/10万,含麻疹成分疫苗为37.36/10万,乙脑(减毒)疫苗为44.96/10万,Hib疫苗为59.06/10万。1 012例AEFI中,男性占57.61%,女性占42.39%,<1岁者占53.46%;临朐县占18.58%,寿光市占13.74%,潍城区占13.54%;5～6月占28.26%。一般反应的994例中,发热占62.47%,局部红肿占26.26%;异常反应的14例,卡介苗淋巴结炎和过敏性皮疹分别占35.71%和64.29%。全市报告县覆盖率、48h报告及时率、48h调查及时率和个案调查完整率均达到100.00%。结论全市2012年AEFI主要发生在小年龄儿童,使用疫苗不良反应报告发生率均在预期发生范围内,安全性良好。
Objective To analyze the occurrence characteristics of suspected AEFI in 2012 in Weifang City and evaluate the operation of AEFI monitoring system and the vaccination safety. Methods A descriptive epidemiological method was used to analyze the AEFI case data reported by Weifang from January 1 to December 31, 2012. Results Weifang City in 2012 a total of 1 012 cases of AEFI report, the report rate was 36.76 / 100000. The incidence of the report was 36.10 / 100,000 with an abnormal response of 0.51 / 100,000, with a coupling rate of 0.07 / 100,000 and a psychogenic response of 0.04 / 100,000; a trial of diphtheriae (cell free) vaccine at 109.84 / 10 The number of meningitis A + C combined vaccines was 83.50 / 100,000, including 37.36 / 100,000 for measles components, 44.96 / 100,000 for JE (attenuated) vaccines and 59.06 / 100,000 for Hib vaccines. 1 012 cases of AEFI, men accounted for 57.61%, women accounted for 42.39%, <1 year old accounted for 53.46%; Linqu County accounted for 18.58%, Shouguang City accounted for 13.74%, Weicheng District accounted for 13.54%; May to June accounted for 28.26%. In the 994 cases of general reaction, fever accounted for 62.47%, local swelling accounted for 26.26%; abnormal reaction in 14 cases, BCG lymph node inflammation and allergic rash accounted for 35.71% and 64.29%. The city reported the county coverage, 48h report timely rate, 48h survey and the case-time rate of complete investigation rate reached 100.00%. Conclusion The AEFI in 2012 mainly occurred in the small-aged children in the city. The incidence of adverse drug reactions reported in the hospital was within the expected range and the safety was good.