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目的 观察奈替米星治疗反复泌尿系感染的疗效和肾毒性 .方法 对 2 3例反复泌尿系感染者 ,中段尿培养致病菌株对奈替米星敏感而使用奈替米星 ,根据肌酐清除率调整用药剂量 ,在治疗后复查血、尿常规、血尿素氮、肌酐 ,尿渗透压、肌酐清除率及尿培养 .对用药前有肾功能损害的患者 ,治疗后随诊 3个月 ,观察肾功能的变化 .结果 奈替米星治疗敏感病菌株引起的泌尿系感染的临床治愈率是 81.8% ,临床有效率是 90 .9% .治疗期间和结束后随诊期间 ,未见肾毒性和其它明显的副作用 .结论 奈替米星治疗反复泌尿系感染是安全有效的
Objective To observe the curative effect and nephrotoxic effect of netilmicin in the treatment of recurrent urinary tract infections.Methods Twenty-three patients with recurrent urinary tract infection and mid-stage urinary culture were used netilmicin to be sensitive to netilmicin, Rate adjustment dose, after treatment, blood, urine routine examination, blood urea nitrogen, creatinine, urine osmolality, creatinine clearance and urine culture.For patients with renal dysfunction before treatment, followed up for 3 months after treatment Results The clinical cure rate of netilmicin in treating urinary tract infection was 81.8%, and the clinical effective rate was 90.9%. Nephrotoxicity and nephrotoxicity were not observed during and after treatment Other obvious side effects.CONCLUSION Netilmicin is safe and effective in the treatment of recurrent urinary tract infections