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1954年Chao等首先报道了全脑放射治疗(WBRT)对脑转移癌有姑息性治疗效果。然而WBRT后发展成进展型脑转移则是对临床医师的挑战。治疗方法有外科、重复的WBRT或立体放射外科。作者收集了1975～1993年2658例接受WBRT的脑转移病人,其中86例因影像学发现及神经系统的异常诊为进展型脑转移。男52例,女34例,平均年龄58岁。31例来自乳腺,31例来自肺,结肠肿瘤6例,黑色素瘤5例,不明6例,其他5例。从
In 1954, Chao et al first reported that whole brain radiation therapy (WBRT) has a palliative effect on brain metastases. However, the development of progressive brain metastases after WBRT is a challenge to clinicians. Surgical treatment, repeated WBRT or stereotactic radiosurgery. The authors collected 2658 patients with brain metastases who underwent WBRT from 1975 to 1993, 86 of whom were diagnosed with progressive brain metastases due to imaging findings and abnormalities in the nervous system. There were 52 males and 34 females, with an average age of 58 years. 31 cases came from the breast, 31 cases from the lungs, colon tumors in 6 cases, melanoma in 5 cases, unknown in 6 cases and other 5 cases. From