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目前有20%以上的败血症患者合并呼吸衰竭,而现有治疗方法常难以奏效。据统计,败血症性肺损伤(Septic lung injury,SLI)是住院病人发生呼吸功能不全的主要原因。败血症性休克发生呼吸窘迫综合征(ARDS)者,死亡率高达90%。作者复习了败血症时肺血液动力学及功能性变化特点的有关资料,以及血小板、中性粒细胞、补体、花生四烯酸代谢产物和纤维蛋白衍生的肽类在败血症性呼吸功能障碍中的作用,并讨论了与上述因素有关的相应治疗措施。【败血症时肺的结构与功能变化】
Currently, more than 20% of sepsis patients with respiratory failure, and the current treatment is often difficult to work. It is estimated that septic lung injury (SLI) is the main cause of respiratory insufficiency in hospitalized patients. Septic shock Respiratory distress syndrome (ARDS), the mortality rate as high as 90%. The authors reviewed data on pulmonary hemodynamic and functional changes in sepsis and the role of platelets, neutrophils, complement, arachidonic acid metabolites, and fibrin-derived peptides in septic respiratory dysfunction , And discussed the corresponding treatment of these factors. Changes in the structure and function of the lung during sepsis