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本文报道了南斯拉夫萨格勒布市肿瘤及相关疾病研究中心对31例不能手术的食管癌患者行博莱霉素与阿霉素联合化疗,或再加放疗的综合治疗的随机分组研究。全部病人皆为81岁以下的中1/3或下1/3的食管癌。有活动性心脏病的食管癌患者不选入。体力状况属Karnofsky 分级法5～7级者18例,2～4级者13例。仅博莱霉素和阿霉素二者为联合化疗组计16例,二药外加放疗是为综合治疗组计15例。二组在性别、年龄及肿瘤部位基本相同。治疗方法:联合化疗组第一、四天静脉给予博莱霉素15mg/m~2,第二、三天静脉给予阿霉素40mg/m~2
In this paper, a randomized subgroup study of 31 patients with inoperable esophageal cancer who underwent combined chemotherapy with bleomycin and adriamycin plus radiotherapy or radiotherapy was reported in the Zagreb City Center for Tumor and Related Diseases in Yugoslavia. All patients were middle or third-third of esophageal cancer below 81 years of age. Esophageal cancer patients with active heart disease are not selected. The physical condition was in the Karnofsky classification of grades 5 to 7 in 18 cases, and grades 2 to 4 in 13 cases. Only bleomycin and adriamycin were included in the combined chemotherapy group. There were 15 cases in the comprehensive treatment group. The two groups were basically the same in terms of gender, age, and tumor site. Treatment: Bleomycin 15mg/m~2 was given intravenously on the first and fourth day of the combined chemotherapy group, and 40mg/m~2 was administered intravenously on the second and third days.