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目的:探讨上皮细胞粘附分子E-钙粘附素(E-CD)和β-链接蛋白(β-CA)在胃癌组织中的表达及其与胃癌生物学行为的关系。方法:采用免疫组化技术对80例手术切除的新鲜胃癌组织及癌周正常组织标本进行E-CD和β-CA表达情况检测,并同时行腹腔脱落癌细胞学检查。结果:胃癌组织E-CD和β-CA的表达降低或缺失率分别为78.75%(63/80)和61.25%(49/80);在浸润型、未分化型、弥漫状生长、有淋巴结转移及Ⅲ、Ⅳ期胃癌中,E-CD和β-CA表达明显降低或缺失(P<0.01);在浆膜分型中的腱状、多彩弥漫型和浸润深度中的se、si及腹腔脱落癌细胞阳性病例中,E-CD和β-CA表达亦明显降低或缺失(P<0.05)。结论:E-CD和β-CA联合检测对评估胃癌浸润深度、淋巴结转移、TNM分期、浆膜受侵及腹腔腹膜转移等情况具有较大意义。
Objective: To investigate the expression of epithelial cell adhesion molecules E-cadherin (E-CD) and β-catenin (β-CA) in gastric carcinoma and its relationship with the biological behavior of gastric cancer. Methods: Immunohistochemical technique was used to detect the expression of E-CD and β-CA in 80 cases of fresh gastric cancer tissue and normal tissue around the cancer. Results: The expressions of E-CD and β-CA in gastric cancer tissues were significantly lower than those in controls (78.75% (63/80) and 61.25% (49/80), respectively). In invasive, undifferentiated, diffuse, lymph node metastasis (P <0.01). In serous type, diffuse serous and diffuse infiltration depth and se, si and peritoneal cavity shedding In the positive cases of cancer cells, the expressions of E-CD and β-CA were also significantly decreased or absent (P <0.05). Conclusion: The combined detection of E-CD and β-CA is of great significance in assessing the depth of invasion, lymph node metastasis, TNM stage, serosa invasion and peritoneal metastasis.