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本研究旨在分析非霍奇金淋巴瘤(NHL)的临床资料,探讨影响预后的因素。对125例NHL病例进行了回溯性分析。结果发现,125例病例中B-NHL85例(68%),T-NHL35例(28%),不能分类的5例(4%)。B-NHL易于侵犯骨髓,而T-NHL多伴有B症状,乳酸脱氢酶(LDH)升高,临床分期晚,国际预后指数(IPI)评分高,且T-NHL的3年存活率明显低于B-NHL。生存分析显示,年龄、B症状、LDH水平、临床分期为预后相关因素,免疫分型对预后无显著性影响。骨髓侵犯的发生率为31.2%(39/125),在B-NHL多见。骨髓侵犯方式与年龄、B症状、LDH水平、T/B免疫分型无关,但弥漫型骨髓侵犯多伴有肝脾肿大,且总体生存率明显低于局灶型。结论:年龄、B症状、LDH水平和临床分期是影响NHL预后的主要因素,免疫分型尚不足以成为判断预后的独立因素,骨髓侵犯方式对预后有一定的提示意义。
This study aimed to analyze the clinical data of non-Hodgkin’s lymphoma (NHL) and explore the factors that influence the prognosis. A retrospective analysis of 125 NHL cases was performed. RESULTS: Eighty-five cases (68%) had B-NHL in 125 cases, 35 (28%) had T-NHL, and 5 (4%) failed to classify. B-NHL is easy to invade the bone marrow, and T-NHL often accompanied by symptoms of B, elevated lactate dehydrogenase (LDH), clinical stage, the International Prognosis Index (IPI) score was high, and T-NHL 3-year survival was significantly Lower than B-NHL. Survival analysis showed that age, B symptoms, LDH level and clinical stage were prognostic factors, and immunophenotyping had no significant effect on prognosis. The incidence of bone marrow invasion was 31.2% (39/125), more common in B-NHL. Bone marrow invasion and age, B symptoms, LDH level, T / B immunophenotype has nothing to do, but more diffuse bone marrow involvement associated with hepatosplenomegaly, and overall survival was significantly lower than focal. CONCLUSION: Age, B symptoms, LDH level and clinical stage are the main factors affecting the prognosis of NHL. Immunophenotyping is not enough to be an independent factor in predicting prognosis. The way of bone marrow invasion has some implications for prognosis.