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由于诊治技术的进步,小儿急性白血病的疗效明显改进,根治病例增加,长期生存病例中存在的各种损伤引人注意。小儿急性白血病的晚期损伤定义为:小儿期发病的急性白血病患者停止治疗获得长期生存时,因疾病本身的侵袭或各种治疗引起的直接、间接损伤。晚期损伤包括疾病发病时存在的损伤,诱导缓解、中枢神经系统预防治疗、维持治疗中发生的损伤,以及治疗结束后发生的损伤。日本血液学专科调查全国儿科的急性淋巴性白
Due to the improvement of diagnosis and treatment technology, the curative effect of acute leukemia in children is obviously improved, and the radical cases are increased. All kinds of injuries existing in long-term survival cases attract attention. Late injury in children with acute leukemia is defined as: Pediatric acute leukemia in patients with acute leukemia to stop treatment to obtain long-term survival, due to the invasion of the disease itself or a variety of treatment-induced direct and indirect damage. Advanced lesions include damage present at the onset of the disease, induction remission, CNS prophylaxis, damage sustained during maintenance therapy, and damage that occurs after treatment. Japanese hematology specialist investigation of the national pediatric acute lymphoid white