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目的观察多潘立酮联合阿米替林治疗功能性消化不良的临床效果。方法将医院收治的84例功能性消化不良患者随机分为观察组和对照组每组各42例。对照组采用多潘立酮治疗,观察组在对照组基础上联合阿米替林治疗,比较2组治疗总有效率、症状缓解时间和不良反应发生情况。结果观察组总有效率为95.24%,高于对照组的71.43%(P<0.05);观察组症状缓解时间为(4.25±1.23)d,短于对照组的(8.35±2.26)d(P<0.05)。2组均未出现明显不良反应。结论多潘立酮联合阿米替林治疗功能性消化不良,可提高治疗有效率,症状缓解快,不良反应少,值得在临床推广应用。
Objective To observe the clinical effect of domperidone combined with amitriptyline in the treatment of functional dyspepsia. Methods Eighty-four patients with functional dyspepsia admitted to the hospital were randomly divided into observation group (42 cases) and control group (42 cases). The control group was dominated by domperidone, and the observation group was treated with amitriptyline on the basis of the control group. The total effective rate, symptom relief time and adverse reactions in the two groups were compared. Results The total effective rate in observation group was 95.24%, which was higher than 71.43% in control group (P <0.05). The symptom relief time in observation group was (4.25 ± 1.23) d, shorter than that in control group (8.35 ± 2.26) d (P < 0.05). No obvious adverse reactions occurred in both groups. Conclusion Domperidone combined with amitriptyline in the treatment of functional dyspepsia, can improve the efficiency of treatment, rapid relief of symptoms, fewer adverse reactions, it is worth in the clinical application.