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目的探讨超声联合HE4检测在卵巢癌中的诊断价值。方法回顾性分析唐山市妇幼保健院2012年9月-2014年10月收治住院的卵巢肿瘤患者120例,其中恶性肿瘤38例,良性肿瘤82例;同时选取健康妇女50例为对照组,所有受检者均经彩色多普勒超声检查卵巢。采用电化学发光法检测受检者HE4的含量,应用ROC曲线分析超声检查和HE4对卵巢癌的诊断价值。结果卵巢癌组患者全血HE4明显高于卵巢良性肿瘤组和对照组。ROC曲线分析显示,超声检查、HE4及两者联合检测诊断卵巢癌的ROC曲线下的面积分别为0.877、0.721和0.917,联合诊断效率高于两者单独使用。结论超声联合肿瘤标志物HE4检测可以很好地鉴别卵巢良恶性肿瘤,具有较高的诊断价值。
Objective To investigate the diagnostic value of ultrasound combined with HE4 in ovarian cancer. Methods A retrospective analysis of Tangshan MCH hospital from September 2012 to October 2014 admitted to hospital 120 cases of ovarian cancer patients, including 38 cases of malignant tumors, benign tumors in 82 cases; the same time, 50 healthy women were selected as the control group, all The seizures were color Doppler ultrasound examination of the ovary. The content of HE4 was detected by electrochemiluminescence. The diagnostic value of ultrasonography and HE4 on ovarian cancer was analyzed by ROC curve. Results Whole blood HE4 in patients with ovarian cancer was significantly higher than that in benign ovarian tumors and controls. ROC curve analysis showed that the areas under the ROC curves of ultrasound examination, HE4 and the combination detection of the two were 0.877, 0.721 and 0.917 respectively, and the diagnostic efficiency of combined diagnosis was higher than that of the two alone. Conclusion Ultrasound combined with HE4 detection of tumor markers can well differentiate benign and malignant tumors of ovary, which is of high diagnostic value.