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青年胃印戒细胞癌是临床上预后较差的恶性肿瘤。为了研究该肿瘤患者的免疫状态及应用γδＴ淋巴细胞治疗可能性，对４例青年胃印戒细胞癌患者、６例正常人外周血作了免疫细胞表型分析（ＣＤ３、ＣＤ４、ＣＤ８、ＣＤ１６、ＣＤ２５、ＣＤ５６、Ｔγδ）及肿瘤坏死因子（ＴＮＦ）和白细胞介素６（ＩＬ－６）检测。并对４例患者采用γδＴ细胞／ＩＬ－２过继免疫治疗（ＡＣＩＴ），观察细胞免疫动态变化。结果表明：４例青年胃印戒细胞癌患者外周血ＣＤ＋３、ＣＤ＋４、ＣＤ＋４／ＣＤ＋８比值均低于正常组。ＴＮＦ、ＩＬ－６水平均高于正常组；γδＴ细胞治疗后，外周血ＣＤ＋３、ＣＤ＋４、ＣＤ＋４／ＣＤ＋８比值均升高。随访病人１０～２５个月，未见转移、复发，身体情况均好
Young stomach signet ring cell carcinoma is a malignant tumor with a poor prognosis. In order to study the immune status of this patient and the possibility of using γδT lymphocyte therapy, immunophenotypic analysis (CD3, CD4, CD8, CD16) was performed on 4 cases of young patients with gastric signet-ring cell carcinoma and 6 normal controls. Detection of CD25, CD56, Tγδ), Tumor Necrosis Factor (TNF) and Interleukin 6 (IL-6). Four patients were treated with γδT cells/IL-2 adoptive immunotherapy (ACIT) to observe the dynamic changes of cellular immunity. The results showed that the ratios of CD+3, CD+4, and CD+4/CD+8 in the peripheral blood of 4 young patients with gastric signet-ring cell carcinoma were lower than those in the normal group. The levels of TNF and IL-6 were higher than those of the normal group. After treatment with γδT cells, the ratios of CD+3, CD+4, and CD+4/CD+8 in peripheral blood were all increased. Follow-up patients for 10 to 25 months, no metastases, recurrences, and good physical condition