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设计和合成了一系列由联二萘酚衍生的手性亚磷酸酯配体.这些配体与铑(Ⅰ)形成的络合物能够有效地催化苯乙烯和乙酸乙烯酯的不对称氢甲酰化反应,显示高度的催化活性、化学选择性和较好的区域选择性(异构醛/正构醛).最高对映选择性分别达到37.0％和38.1％.手性双齿亚磷酸酯配体与单齿亚磷酸酯配体相比,产生更好的对映选择性,但是更低的区域选择性.
A series of chiral phosphite ligands derived from bisnaphthol were designed and synthesized.The complexes formed by these ligands with rhodium (Ⅰ) were able to efficiently catalyze the asymmetric hydrogenation of styrene and vinyl acetate The results showed that the highest enantioselectivity was 37.0% and 38.1%, respectively. Chiral bidentate phosphite with the highest selectivity, selectivity and selectivity (isomeric aldehyde / n-alkanal) The body produces better enantioselectivity but a lower regioselectivity than monodentate phosphite ligands.