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目的了解四川省西昌市静脉吸毒人群艾滋病疫苗临床试验接种意愿情况。方法于2004年11~12月,调查艾滋病病毒血清抗体阴性的静脉吸毒者99人,内容包括社会人口学、高危吸毒和性行为、参加艾滋病疫苗临床试验的接种意愿及其动机、可能带来的好处和担心。结果在调查的99名静脉吸毒人群中,57.6%的人明确表示愿意参加艾滋病疫苗临床试验。多因素Logistic回归模型分析结果显示,家庭支持参加今后的艾滋病疫苗临床试验(OR,9.45;95%CI,3.48~25.68)和担心由于参加艾滋病疫苗临床试验他人不愿意与之来往(OR,0.35;95%CI,0.13~0.97)与艾滋病疫苗接种意愿的关系有统计学意义。结论需开展艾滋病疫苗临床试验接种的社区健康教育来提高其接种意愿,为我国开展大规模艾滋病疫苗临床试验做好准备。
Objective To understand the willingness to inoculation of HIV vaccine clinical trials among intravenous drug users in Xichang, Sichuan Province. Methods From November to December 2004, 99 HIV-negative drug users were surveyed, which included social demography, high-risk drug abuse and sexual behaviors, the willingness to inoculate in AIDS vaccine clinical trials and their possible motivations. Benefits and fears. Results Of the 99 intravenous drug users surveyed, 57.6% of them clearly expressed their willingness to participate in AIDS vaccine clinical trials. Multivariate logistic regression analysis showed that families supported the participation of future AIDS vaccine clinical trials (OR, 9.45; 95% CI, 3.48-25.68) and feared unwilling interactions with people who participated in AIDS vaccine trials (OR, 0.35; 95% CI, 0.13 ~ 0.97) and the willingness of AIDS vaccination were statistically significant. Conclusion Community health education to be vaccinated in clinical trials of AIDS vaccines needs to be carried out to enhance their willingness to vaccinate and prepare for the clinical trials of large-scale AIDS vaccines in China.