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苯巴比妥 (ｐｈｅｎｏｂａｒｂｉｔａｌ,ＰＢ)被视为小儿癫痫首选药 ,常与其他抗癫痫药联用治疗难治性癫痫。有关联合苯巴比妥用药对血药浓度的影响已有一些报道。但儿童联合用药对ＰＢ血浓度的影响报道未见。本文就 1～ 12岁的 117例联用苯巴比妥与丙戊酸盐 (ｖａｌｐｒｏａｔ
Phenobarbital (PB) is considered as the drug of choice for children with epilepsy and is often used in combination with other antiepileptic drugs to treat refractory epilepsy. There are some reports about the effect of combination of phenobarbital on blood concentration. However, there is no report on the effect of combination therapy of children on PB blood concentration. 117 cases of 1 to 12 years old combined phenobarbital and valproate (valproat