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在急性胰腺炎病程中80％以上患者死于并发感染。胰腺炎相关的脓毒性并发症中最常见的致病菌是大肠杆菌属,提示结肠是其可能的来源。另外,研究发现小肠灌洗加上滴注卡那霉素降低了实验性出血性胰腺炎死亡率。作者用确立的急性坏死性胰腺炎的模型来研究用不吸收的抗生素及泻剂清洁肠道的治疗效果。 方法:200只重200～240g雄性大鼠腹腔内戍巴比妥麻醉后剖腹,经十二指肠作胰胆管插管,经此管注入溶于双甘氨肽-氢氧化钠缓冲液
In the course of acute pancreatitis more than 80% of patients died of concurrent infection. The most common causative agent of pancreatitis-associated septic complications is Escherichia, suggesting that the colon is its possible source. In addition, the study found that small bowel irrigation combined with drip kanamycin reduced experimental hemorrhagic pancreatitis mortality. The authors used a model of established acute necrotizing pancreatitis to study the effect of cleaning intestinal tract with nonabsorbed antibiotics and laxatives. Methods: 200 male rats weighing 200 ~ 240g were anesthetized intraperitoneally with cesarean section and peritoneal ducts for pancreaticobiliary intubation. After injecting this solution into the double glycine peptide-sodium hydroxide buffer