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本文报告1982年4月～1983年6月期间在美印弟安纳州4例接受口服灰质炎疫苗(OPV)婴儿发生与疫苗有关的神经系统并发症。该例均被误诊。第一例为1名1岁男婴,于接受首剂百白破疫苗(DTP)与OPV 后22天起出现发热、易激惹及左腿无力。入院体检仅发现左腿弛缓性瘫痪,感觉正常。脑脊液WBC23/mm~3,葡萄糖54mg/dl,蛋白131mg/dl。血清免疫球蛋白正常水平。血清补体、T 和B 细胞数、T 细胞亚群、PHA 淋巴细胞刺激试验、体感
This article reports on vaccine-related neurological complications in 4 infants who received oral polio vaccine (OPV) infants in the Indo-American, Indiana region between April 1982 and June 1983. The cases were misdiagnosed. The first case was a 1-year-old boy who developed fever, irritability and left leg weakness on the 22nd day after receiving the first dose of diphtheria toxoid (DTP) and OPV. Physical examination found only left leg flaccid paralysis, normal feeling. Cerebrospinal fluid WBC23 / mm ~ 3, glucose 54mg / dl, protein 131mg / dl. Serum immunoglobulin normal level. Serum Complement, T and B Cell Count, T Cell Subset, PHA Lymphocyte Stimulation Test, Somatosensory