论文部分内容阅读
目的:探讨胃癌与C型行为的相关性,研究胃癌患者的心理行为因素对各免疫指标(IgG、IgA、IgM、C3、CD3+、CD4+、CD8+、NK细胞含量)的影响。方法:总体样本140例,其中胃癌组70例,正常对照组70例按1∶1配比。所有胃癌组在手术前和正常对照组均完成C型行为量表,并同时抽取静脉血检查免疫全套和NK细胞含量。用t检验、χ2检验、多元逐步回归分析等方法,在计算机上完成数据的统计处理。结果:(1)胃癌组在焦虑、抑郁、愤怒、合理化、控制和愤怒向内等因子得分均明显高于正常对照组(P<0.05或P<0.01),而在愤怒向外、乐观、社会支持等因素得分明显低于正常对照组(P<0.05),胃癌组9个因子结果均符合C型行为特征。(3)胃癌患者外周血IgG、IgA的含量、T淋巴细胞亚群CD3+、CD4+及NK细胞含量显著低于正常对照组(P<0.05或P<0.01)。多元逐步回归分析结果显示,CD4+细胞的多少与抑郁、愤怒、合理化等因子得分值呈负相关(P<0.05或P<0.01),NK细胞含量与愤怒向外、乐观、社会支持等因子得分呈正相关(P<0.05或P<0.01)。IgA的含量与经济状况呈正相关。结论:胃癌发病患者的心理行为特征与C型行为特征密切相关。C型行为因素对胃癌患者的免疫起着不可低估的作用。
Objective: To investigate the correlation between gastric cancer and C-type behavior and to study the influence of psychological and behavioral factors on immune indicators (IgG, IgA, IgM, C3, CD3 +, CD4 +, CD8 +, NK cell content) in patients with gastric cancer. Methods: The overall sample of 140 cases, of which 70 cases of gastric cancer group, 70 cases of normal control by 1: 1 ratio. All gastric cancer group before surgery and normal control group were completed C-type behavior scale, while taking venous blood to check the complete set of immune and NK cell content. Using t test, χ2 test, multiple stepwise regression analysis and other methods to complete the statistical data processing on the computer. Results: (1) The score of factors such as anxiety, depression, anger, rationalization, control and anger in gastric cancer group were significantly higher than those in normal control group (P <0.05 or P <0.01) Support and other factors were significantly lower than the normal control group (P <0.05), the results of 9 factors in gastric cancer group are consistent with the C-type behavioral characteristics. (3) The contents of IgG and IgA in peripheral blood and the levels of CD3 +, CD4 + and NK cells in T lymphocyte subsets were significantly lower than those in normal control group (P <0.05 or P <0.01). Multiple stepwise regression analysis showed that there was a negative correlation between the number of CD4 + cells and scores of factors such as depression, anger and rationalization (P <0.05 or P <0.01), NK cell content and scores of anger outward, optimistic and social support (P <0.05 or P <0.01). IgA content and economic status was positively correlated. Conclusion: Psychological and behavioral characteristics of patients with gastric cancer are closely related to C-type behavioral characteristics. C-type behavioral factors play an important role in the immunization of patients with gastric cancer.