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目的探讨胆碱酯酶(ChE)联合血小板参数对慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的预测价值。方法选择2013年6月—2015年6月麻城市人民医院收治的AECOPD患者120例,根据患者入院时的动脉血气分析结果,将其分为B组(未并发呼吸衰竭,n=60)和C组(并发呼吸衰竭,n=60);另选取同时期在本院进行健康体检的健康成年人60例为A组(对照组)。比较3组及C组不同预后患者治疗前后的血清ChE水平和血小板参数。结果 A组患者的血清ChE水平、血小板计数(PLT)及血小板体积(MPV)高于B、C组,而B组患者的血清ChE水平、PLT及MPV高于C组(P<0.05)。治疗后,C组预后良好患者的血清ChE水平、PLT及MPV高于预后不良患者(P<0.05)。结论血清ChE水平、PLT及MPV对AECOPD患者预后有一定的预测价值,血清ChE水平、PLT及MPV较低的AECOPD患者出现预后不良的风险较高。
Objective To investigate the predictive value of cholinesterase (ChE) combined with platelet parameters in the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 120 AECOPD patients admitted to the People’s Hospital of Maocheng City from June 2013 to June 2015 were selected and divided into two groups according to the results of arterial blood gas analysis at admission: group B (n = 60) and C Group (with respiratory failure, n = 60). Another 60 healthy adults who were in our hospital during the same period were selected as group A (control group). The serum ChE levels and platelet parameters of patients with different prognosis before and after treatment in 3 and C groups were compared. Results Serum ChE level, platelet count (PLT) and platelet volume (MPV) in group A were higher than those in group B and C, while serum ChE, PLT and MPV in group B were higher than those in group C (P <0.05). After treatment, serum ChE levels, PLT and MPV in patients with good prognosis in group C were significantly higher than those with poor prognosis (P <0.05). Conclusion Serum ChE level, PLT and MPV have certain predictive value in the prognosis of patients with AECOPD. Serum ChE levels, PLT, and AECOPD patients with low MPV have a higher risk of poor prognosis.