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巴比妥类药物是一较古老的催眠镇静剂.该剂虽有抗痫作用,但对急性脑损伤患者的应用,一向是谨慎的,这是因为该药能抑制呼吸中枢和影响患者的意识状态,从而妨碍观察病情的缘故.自1960年以来,许多动物实验报告指出,巴比妥酸盐(barbiturate)对脑缺氧有保护作用,并能延长生存期限,提高生存率和减轻损伤的程度.1970年以后,随着从脑代谢和脑血循环诸角度所进行的实验研究和临床观察的深入,渐将本剂做为急性脑损伤时降低颅内压,减轻脑水肿和减少脑耗氧量的药物而用于临床.兹就有关问题,综述如下.
Barbiturates are an older hypnotic sedative agent that, although having antiepileptic effects, has always been cautious in patients with acute brain injury because it suppresses the respiratory center and affects the patient’s state of consciousness , Thus obstructing the observation of the condition.Since 1960, many animal experiments have reported that barbiturate has a protective effect on cerebral hypoxia and prolongs survival, increases survival and lessens the damage. After 1970, with the experimental research and clinical observation proceeding from the aspects of brain metabolism and cerebral blood circulation, gradually reducing the intracranial pressure, reducing cerebral edema and decreasing brain oxygen consumption Drugs for clinical use. Here are the relevant issues, summarized below.