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目的:观察醒脾养儿颗粒治疗小儿厌食症的临床疗效及对胃肠激素的影响。方法:将130例厌食症脾胃气虚证患儿随机分为对照组和治疗组各65例。2组均予补锌等治疗,对照组在此基础上口服双歧杆菌四联活菌片,治疗组则口服醒脾养儿颗粒,疗程均为8周,疗程结束后判断临床疗效,治疗前后检测血清胃泌素(GAS)、血浆胃动素(MOT)及血浆神经肽Y(NPY)水平,并比较2组患儿的体重、血红蛋白(Hb)及总蛋白(TP)增长水平。结果:治疗组总有效率93.85%,高于对照组的67.69%,差异有统计学意义(P<0.01)。疗程结束后,2组体重、Hb、TP均有增长,治疗组体重及TP增长幅度高于对照组,差异均有统计学意义(P<0.01),治疗组Hb增长幅度虽较对照组高,但差异无统计学意义(P>0.05)。2组胃肠激素水平均较治疗前上调,差异均有统计学意义(P<0.05),治疗组和对照组相比,上调更加明显,差异有统计学意义(P<0.05)。结论:在补锌基础上加用醒脾养儿颗粒治疗小儿厌食症脾胃气虚证,可以有效改善患儿食欲,增加食量,改善营养状况,增加患儿体重,其机制可能与提高胃肠激素水平有关。
Objective: To observe the therapeutic effect of Xingpi Yangzile Granule on children with anorexia and its effect on gastrointestinal hormones. Methods: 130 cases of anorexia spleen and stomach qi deficiency syndrome were randomly divided into control group and treatment group of 65 cases. Both groups were treated with zinc supplementation. On the basis of the control group, oral live Bifidobacterium quadriceps could be taken orally. The treatment group was orally given Xingnao granule orally for 8 weeks. After the course of treatment, the clinical efficacy was evaluated. Before and after treatment, Serum gastrin (GAS), plasma motilin (MOT) and plasma neuropeptide Y (NPY) levels were compared. The body weight, hemoglobin (Hb) and total protein (TP) Results: The total effective rate in the treatment group was 93.85%, which was higher than that in the control group (67.69%), the difference was statistically significant (P <0.01). At the end of the course of treatment, body weight, Hb and TP both increased, body weight and TP growth rate in the treatment group were higher than those in the control group (P <0.01), Hb growth rate in the treatment group was higher than that in the control group, But the difference was not statistically significant (P> 0.05). Compared with the control group, the levels of gut hormone in the two groups increased significantly compared with those before treatment (P <0.05). The up-regulation of the two groups was more significant than that of the control group (P <0.05). CONCLUSION: The use of Xingpang Yanger Granule in the treatment of infantile anorexia spleen-qi deficiency syndrome can improve appetite, increase appetite, improve nutrition status and increase children’s weight, which may be related to the increase of gastrointestinal hormones .