以小鼠子宫增重法及子宫的组织学检查对抗HCG抗体IgG—F(ab’)_2对HCG的中和作用进行了研究。当用低稀释度F(ab’)_2片段进行中和时,子宫未出现有意义的子宫增重及内膜增生,当用较高稀释度F(ab’)_2片段进行中和时,子宫内膜呈高度水肿、充血及炎细胞浸润,腺体也未见明显增生。本文结果指出,抗HCG抗体与HCG发生中和作用时,抗体的Fc段是不需要的。 The neutralizing effect of HCG antibody IgG-F(ab’)_2 on HCG was studied by mouse uterus weight gain method and histological examination of the uterus. The uterus does not show significant uterine weight gain and intimal hyperplasia when neutralized with a low-dilution F(ab’)2 fragment. When uterus is neutralized with a higher dilution F(ab’)_2 fragment, the uterus The endometrium was highly edematous, hyperemia, and inflammatory cell infiltration. There was no obvious hyperplasia in the glands. The results of this study indicate that the Fc region of antibodies is not required when the anti-HCG antibody neutralizes HCG.