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本文介绍用大剂量苯妥因静脉注射治疗癫痫持续状态、连续性发作和孤立性发作的效果,并确定了与疗效有关的因素。作者在三年中治疗139(男74,女65)例,平均年龄52(17~94)岁。苯妥因的平均剂量为16.4mg/Kg。大多数患者用药前24小时内的发作次数均达3次以上。作者根据对治疗反应的程度将患者分为两组:①反应良好者:包括发作加重的已知癫痫患者75
This article describes the effect of large doses of phenytoin for intravenous treatment of status epilepticus, continuous seizures and solitary seizures, and to determine the factors associated with efficacy. The author treated 139 (male 74, female 65) in three years, with an average age of 52 (17-94) years. The average dose of phenytoin was 16.4 mg / Kg. Most patients within the first 24 hours before the attack were up to 3 times more than the number. The authors divided the patients into two groups according to the extent of response to the treatment: (1) those who responded well: those with known epilepsy who exacerbated