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目的分析2型糖尿病肾脏疾病(T2DKD)患者血清25羟维生素D[25(OH)D]水平与肾功能不全的相关性。方法根据估算肾小球滤过率(e GFR)将133例T2DKD患者分为肾功能不全组及肾功能正常组,采用liason化学发光法测定2组血清25(OH)D水平,收集患者临床指标和生化结果并进行统计学分析。结果 133例T2DKD患者血清25(OH)D水平为(13.07±6.62)nmol/L,其中肾功能不全78例(58.65%),肾功能正常55例(41.35%)。肾功能不全组血清25(OH)D水平明显低于肾功能正常组(P<0.05);肾功能不全组25(OH)D缺乏/不足发生率及缺乏发生率均明显高于肾功能正常组(P均<0.05);多因素线性回归分析提示25(OH)D缺乏/不足(OR=2.383,P=0.013)及血尿酸(OR=8.338,P<0.001)与肾功能不全呈正相关,年龄(OR=0.674,P=0.02)、Hb A1c(OR=0.493,P=0.027)、TG(OR=0.355,P=0.048)与肾功能不全呈负相关。结论 T2DKD患者中25(OH)D缺乏/不足发生率高,25(OH)D缺乏/不足可能是T2DKD患者发生肾功能不全的易患因素。
Objective To investigate the relationship between serum 25-hydroxyvitamin D [25 (OH) D] and renal insufficiency in type 2 diabetic patients with kidney disease (T2DKD). Methods 133 patients with T2DKD were divided into renal dysfunction group and normal renal function group according to estimated glomerular filtration rate (e GFR). Serum 25 (OH) D levels were measured by liason chemiluminescence in two groups, and clinical data of patients And biochemical results and statistical analysis. Results Serum levels of 25 (OH) D in 133 T2DKD patients were (13.07 ± 6.62) nmol / L, of which 78 (58.65%) were renal dysfunction and 55 (41.35%) were normal renal function. Serum 25 (OH) D levels in patients with renal dysfunction were significantly lower than those in patients with normal renal function (P <0.05); 25 (OH) D deficiency / deficiency and renal failure in patients with renal dysfunction were significantly higher than those in patients with normal renal function (P <0.05). Multivariate linear regression analysis showed that there was a positive correlation between 25 (OH) D deficiency and deficiency (OR = 2.383, P = 0.013) and serum uric acid (OR = 8.338, (OR = 0.674, P = 0.02), Hb A1c (OR = 0.493, P = 0.027) and TG (OR = 0.355, P = 0.048) were negatively correlated with renal insufficiency. Conclusion The high incidence of 25 (OH) D deficiency / deficiency in T2DKD patients and the lack of / deficiency of 25 (OH) D may be the predisposing factors of renal dysfunction in T2DKD patients.