原发性肝细胞癌(Primary Hepatocellular Carcinona PHC)是世界十大肿瘤之一,估计每年至少有25万新病例。Sher-lock及Voget等1970年正式提出乙型肝炎病毒Hepatitis B Virus HBV)感染与PHC的关系。继后,国内外学者对HBV与PHC的关系,从流行病学、病理学、细胞及分子生物学等方面做了大量工作,取得了许多HBV感染与PHC关系的证据,现分述如下。流行病学研究一、PHC与HBC感染地区分布一致:在世界不同地区,PHC的发病率与HBsAg的检测率基本是一致的。欧洲、美洲、澳大利亚三洲HBsAg检测率低,PHC发病率也 Primary Hepatocellular Carcinoma PHC is one of the top 10 tumors in the world with an estimated 250,000 new cases a year. Sher-lock and Voget in 1970 formally proposed hepatitis B virus Hepatitis B Virus (HBV) infection and the relationship between PHC. Subsequent, scholars at home and abroad on the relationship between HBV and PHC, from epidemiology, pathology, cells and molecular biology, done a lot of work, made a lot of evidence of HBV infection and PHC relationship, are as follows. Epidemiological study A, PHC and HBC infection in the same area: in different parts of the world, the incidence of PHC and HBsAg detection rate is basically the same. Europe, the Americas, Australia, HBsAg detection rate is low, the incidence of PHC also