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小唐松草碱(ocoteine)1～10 mg/kg iv对麻醉、清醒的正常血压大鼠和肾性高血压大鼠均有迅速而持久的降压作用,脑室内注射给药也有明显的降压作用。切断双侧迷走神经合用阿托品,及用苯海拉明不影响 ocoteine的降压作用。在毁脊髓大鼠,ocoteinc 1～3mg/kg使甲氧明的量效曲线平行右移,而不影响B-HT920的量效曲线。结果提示ocoteine选择性阻断血管性平滑肌突触后α_1受体,并可能具有中枢性降压作用;其降压作用不是通过迷走神经或释放组胺。
Small tootinine (ocoteine) 1 ~ 10 mg / kg iv anesthetized, awake normotensive rats and renal hypertensive rats have rapid and sustained antihypertensive effect, intracerebroventricular injection also had significant antihypertensive effect. Cut bilateral vagal nerve combined with atropine, and diphenhydramine does not affect the octreine antihypertensive effect. In the spinal cord destroyed rats, ocoteinc 1 ~ 3mg / kg so that the dose-effect curve of methoxamine parallel shift without affecting the dose-response curves of B-HT920. The results suggest that ocoteine selectively blocks postsynaptic [alpha] 1 receptors in vascular smooth muscle and may have central antihypertensive effect; its antihypertensive effect is not through the vagus nerve or histamine release.