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以99TcmO4-淋洗液为起始物,在低压条件下制备了中间体[99Tcm(CO)3(H2O)3]+,并通过配体交换反应得到放化纯度大于90％的[99Tcm(CO)3(CHI)3]+配合物。该配合物在室温下放置6 h以上放化纯度无明显变化。在正常昆明小鼠体内的生物分布实验结果表明,[99Tcm(CO)3(CHI)3]+具有一定的心肌摄取,且滞留也相当好;在注射后5 min和60 min时的心肌摄取值分别为(13.59±2.12)％ID/g和(13.87±1.54)％ID/g。尽管该配合物的肝和肺本底摄取较高,但是与99TcmN—CHI和99Tcm-CHI相比,羰基锝中心核的引入还是大大改善了配合物用于心肌显像的性能,为发展新的心肌显像剂提供了一种新思路。
The intermediate [99Tcm (CO) 3 (H2O) 3] + was prepared under low pressure with 99TcmO4-eluent as starting material and the [99Tcm (CO ) 3 (CHI) 3] + complex. The complex was placed at room temperature for 6 h above radiochemical purity no significant change. The results of biodistribution experiments in normal Kunming mice showed that [99Tcm (CO) 3 (CHI) 3] + had some myocardial uptake and retention was also quite good. The myocardial uptake values at 5 min and 60 min after injection (13.59 ± 2.12)% ID / g and (13.87 ± 1.54)% ID / g, respectively. Despite the higher liver and lung background uptake of this complex, the introduction of the carbonyl technetium central nucleus significantly improved the performance of the complex for myocardial imaging compared to 99 Tcm N-CHI and 99 Tcm-CHI, Myocardial imaging agents provide a new way of thinking.