Advanced oxide metallurgy technique was adopted to produce 100-kg Y-bearing 12Cr ferritic/martensitic steel via vacuum induction melting and casting route. Subsequently, nine specimens at top, middle and bottom regions of the sheet were char-acterized to evaluate the homogeneity of chemical composition, microstructure and mechanical properties. The small vibra-tion of hardness (200–220 HBW), ultimate tensile strength (672–678 MPa), yield strength (468–480 MPa), total elongation (26.2%–30.5%) and Charpy energy at room temperature (98–133 J) and at ??40 ℃ (12–40 J) demonstrated that mechanical properties’ homogeneity of Y-bearing steel was acceptable although slight Y segregation and inhomogeneous microstructure occurred at the bottom. Furthermore, the effect of Y content on microstructure characteristics and mechanical properties was explained and the comparison of failure mechanism for the dual-phase steel between tensile test (i.e., quasi-static loading) and Charpy test (i.e., dynamic loading) was discussed in detail.