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作者采用新近合成的一种十肽类药物——Cer-uletide 作小肠钡餐X 线检查的辅助剂,以缩短检查时间。本品与缩胆囊素化学结构类似,仅是以甲硫丁氨酸(methionine)置换缩胆囊素肽链第三位上的β—羟丁氨酸(threonine),它具有增加空肠、回肠、结肠运动,刺激胰腺外分泌,促进胆囊收缩,抑制奥狄氏括约肌的作用。作者将48例分为二组,给药组32例,年龄20～60岁,平均体重74.6公斤,按0.3微克/公斤肌肉注射Ceruletide。对照组16例,年龄24～68岁,平均体重71.3公斤,注射安慰剂(生理盐水)。所有病例检查前均除外肠梗阻、胆石病、急性胰腺炎、严重心血管疾病、肝肾疾病或妊娠。检查前10小时禁食,服钡乳不少于
The authors used a newly synthesized decapeptide drug - Cer-uletide barium meal for small intestine X-ray examination adjuvant to shorten the examination time. This product is similar to the cholecystokinin chemical structure, only methylthionine (methionine) replacement cholecystokinin third position on the β-hydroxy-threonine (threonine), which has increased jejunum, ileum, colon Exercise, stimulate pancreatic exocrine, promote gallbladder contraction, inhibit the role of Oddi sphincter. The authors divided 48 patients into two groups, 32 in the drug group, aged 20-60 years, with an average body weight of 74.6 kg and intramuscular injection of Ceruletide at 0.3 μg / kg. Control group of 16 patients, aged 24 to 68 years, with an average body weight of 71.3 kg, placebo (saline). All cases were excluded before the examination of intestinal obstruction, cholelithiasis, acute pancreatitis, severe cardiovascular disease, liver and kidney disease or pregnancy. Check the first 10 hours fasting, serving no less than barium milk