仅最近才认识到获得性免疫缺乏综合征(acquived immunodeficiency syndrome,AIDS)与免疫调节异常有关,且对机会感染高度敏感,许多患者终至死亡。本综合征是否继发于与多种抗原接触,或系一特殊的传递因子或继发于某种其他机制尚不了解。据报道有3例血友病患者有免疫调节的血清学异常和通常仅在免疫抑制患者中才能见到的疾病。无症状血友病患者中一些患者有免疫调节障碍,其特征为OKT4/OKT8细胞比率异常。研究证实存在此种异常。即抑制(OKT8)细胞数增多。接受市售低压冻干的因子Ⅷ浓缩物似较接受冷沉淀物更可能发生这种T细胞亚群异常。鉴于这种发现,对目前的治 It has only recently been recognized that acquired immunodeficiency syndrome (AIDS) is associated with aberrant immunomodulation and is highly susceptible to opportunistic infections, with many patients eventually dying. Whether this syndrome is secondary to contact with multiple antigens or is a specific delivery factor or is secondary to some other mechanism is not known. It has been reported that 3 patients with hemophilia have immunomodulatory serological abnormalities and diseases that are usually seen only in immunosuppressed patients. Some patients in asymptomatic hemophilia have immunomodulatory disorders characterized by aberrant OKT4 / OKT8 cell ratios. Studies confirm the existence of such abnormalities. That inhibition (OKT8) increased cell number. Commercially available lyophilized factor VIII concentrates are more likely to develop this subset of T cell abnormalities than are cold sinks. Given this discovery, the current rule