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目的分析人免疫缺陷病毒(HIV)感染者中出现的自身抗体和自身免疫现象。方法回顾性分析经间接免疫荧光法检测过自身抗体的HIV感染者的临床和相关实验室指标。结果共有19例HIV感染者检测了自身抗体,明确合并银屑病、溃疡性结肠炎、特发性血小板减少性紫癜(ITP)的患者各1例;8例出现风湿性症状,主要表现为原因不明的皮疹(5例)、关节疼痛(2例)和肌痛(1例)。10例自身抗体检测结果阳性,出现的自身抗体分别为抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗线粒体抗体(AMA)、抗细胞骨架抗体(CS)、抗胃壁细胞抗体(AP-CA)。自身抗体阳性组患者的IgG和IgA水平明显高于自身抗体阴性组(P<0.05)。结论HIV感染者中可检测出自身抗体,而且可以合并有自身免疫病或免疫亢进的现象。
Objective To analyze the autoantibodies and autoimmunity that occur in people infected with human immunodeficiency virus (HIV). Methods Retrospective analysis of clinical and related laboratory parameters of HIV-infected individuals tested for autoantibodies by indirect immunofluorescence. Results A total of 19 cases of HIV-infected individuals tested for autoantibodies, one case of clear combination of psoriasis, ulcerative colitis and idiopathic thrombocytopenic purpura (ITP); 8 cases of rheumatic symptoms, mainly for reasons Unidentified rash (5 cases), joint pain (2 cases) and myalgia (1 case). 10 cases of autoantibodies were positive, the autoantibodies were ANA, SMA, AMA, CS, AP- CA). The levels of IgG and IgA in autoantibody positive patients were significantly higher than those in autoantibody negative patients (P <0.05). Conclusions Autoantibodies can be detected in HIV-infected individuals and may be associated with autoimmune diseases or hypersensitivity.