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作者进行了青蒿琥酯用于预防血吸虫病的现场观察,于1993年秋在鄱阳湖重疫区矶山村,按双盲配对分服青蒿琥酯和安慰剂(对照)两组共185对.剂量为6mg/kg顿服,每wk服1次,试验期共服药8次,在停止服药后4wk进行效果评价,粪检用Kato-Katz法加孵化.治后复查,服青蒿琥酯185例全部阴性;对照组166例,阳性率4.22%,EPG几何均数35.5±8.9只.服药期间主要副反应与对照组比较无显著差别.服药中、后作血、尿常规和肝、肾功能及心电图检查均在正常值范围内.
The authors conducted an on-site observation of artesunate for the prevention of schistosomiasis. In the autumn of 1993, a total of 185 pairs of artesunate and placebo (control) were co-administered in double-blind pairs in Rocky Mountain Village, Poyang Lake. A dose of 6mg / kg Dayton clothing, wk service 1 times, a total of 8 times during the trial, the effect was evaluated 4wk after stopping the medication, fecal seizures with Kato-Katz method plus post-treatment review, serving artesunate 185 Cases were all negative; the control group of 166 cases, the positive rate of 4.22%, EPG geometric mean of 35.5 ± 8.9 .During the medication side of the main side effects compared with the control group no significant difference in medication, after blood, urine and liver and kidney function And ECG tests are in the normal range.