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本文报告应用琼脂单向扩散法和放射免疫法对细菌性前列腺炎、非细菌性前列腺炎、抗精子抗体阳性、无精子症、少精子症病人共130例的血清及精浆IgG、IgA、IgM、补体C_3和C_4进行定量研究。各研究组血清免疫球蛋白和补体含量在正常范围。精浆IgG和SIgA的检出率是100％,在所有精浆标本中未测到IgM。各研究组中仅细菌性前列腺炎患者精浆IgG、SIgA、补体C_3和C_4的含量有意义地增高,具有临床诊断价值。抗精子抗体阳性患者血清T-T精子凝集抗体滴度高于精浆呈正相关,说明T-T精子抗体(IgG或IgA)可以进入精浆,但其血清及精浆Igs和补体量无明显改变。作者对其机理和免疫动力学进行了讨论,认为研究诊断免疫性不育症,检测血清、精浆、精子表面的抗精子抗体和补体是重要的。
This article reports the use of agar unidirectional diffusion and radioimmunoassay of bacterial prostatitis, non-bacterial prostatitis, anti-sperm antibody-positive, azoospermia, oligospermia patients a total of 130 cases of serum and seminal plasma IgG, IgA, IgM , Complement C_3 and C_4 for quantitative study. Each study group serum immunoglobulin and complement levels in the normal range. The detection rate of seminal IgG and SIgA was 100%, and no IgM was detected in all seminal plasma samples. Serum IgG, SIgA, complement C_3 and C_4 in patients with bacterial prostatitis were significantly increased in all study groups, which had clinical value. Serum T-T sperm agglutination antibody titers in patients with antisperm antibody positive were higher than those in seminal plasma, indicating that T-T sperm antibodies (IgG or IgA) could enter the seminal plasma, but there was no significant change in serum and seminal plasma Igs and complement. The authors discussed their mechanism and immunological kinetics and considered it important to study the diagnosis of immunological infertility and the detection of anti-sperm antibodies and complement on serum, seminal plasma, and sperm surfaces.