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目的:观察以胃舒散为主的三联疗法(胃舒散、头孢氨苄缓释片和庆大霉素)治疗湿热郁结型消化性溃疡合并胃炎的临床疗效以及幽门螺杆菌(Hp)的根除效果。方法:将160例患者随机分为治疗组88例和对照组72例,治疗组予胃舒散、庆大霉素注射液、头孢氨苄缓释片的三联疗法。对照组服用法莫替丁胶囊。治疗前后根据划分标准对临床症状、内镜观察溃疡程度进行评分登记,并记录Hp检测情况。结果:总有效率治疗组为93.2%,对照组为47.2%,治疗组疗效明显优于对照组,差异有非常显著性意义(P<0.01)。治疗组88例治疗后Hp阴转78例,根除率为88.6%;对照组72例治疗后阴转仅13例,根除率为18.1%。2组比较,治疗组Hp根除率明显优于对照组,差异有非常显著性意义(P<0.01)。2组治疗前各项观察指标评分比较,差异无显著性意义(P>0.05)。对照组治疗后以胃脘痛、嗳气、反酸症状改善明显,差异有非常显著性意义(P<0.01),腹胀、胃镜下胃炎程度积分亦有改善,差异有显著性意义(P<0.05);而治疗组治疗后各项指标改善明显,差异有非常显著性意义(P<0.01)。治疗组治疗后各项指标与对照组治疗后比较,差异均有非常显著性意义(P<0.01)。治疗组有3例出现恶心,无呕吐;2例大便溏泻,副反应发生率为5.7%。对照组有5例口干;3例便秘,副反应发生率为11.1%。所有患者均未因此中断治疗,2组副反应比较,差异无显著性意义(P>0.05)。结论:以胃舒散为主的三联疗法治疗湿热郁结型消化性溃疡合并胃炎疗效佳,副作用少,费用低廉,是一种根除Hp的较好方案。
OBJECTIVE: To observe the clinical efficacy of triple therapy (Weishu San, cefalexin sustained-release tablets and gentamycin) in the treatment of peptic ulcer with peptic ulcer combined with gastritis and the eradication effect of Helicobacter pylori (Hp) . Methods: One hundred and sixty patients were randomly divided into treatment group (n = 88) and control group (n = 72). The treatment group was given triple therapy of Weishu powder, gentamycin injection and cefalexin sustained-release tablets. The control group took famotidine capsules. Before and after treatment according to the division criteria for clinical symptoms, ulcer endoscopy score registration, and record Hp detection. Results: The total effective rate was 93.2% in the treatment group and 47.2% in the control group. The curative effect in the treatment group was significantly better than that in the control group, with significant difference (P <0.01). In the treatment group, 88 cases were treated with Hp and 78 cases were everted. The eradication rate was 88.6%. In the control group, only 72 cases were cured, the eradication rate was 18.1%. In the two groups, the Hp eradication rate in the treatment group was significantly better than that in the control group, with significant difference (P <0.01). There was no significant difference between the two groups before treatment (P> 0.05). Gastric stomachache, belching and acid reflux symptoms were significantly improved in the control group after treatment, the difference was significant (P <0.01), abdominal distension and gastritis degree gastritis score also improved, the difference was significant (P <0.05) ; While the treatment group improved significantly after treatment of various indicators, the difference was very significant (P <0.01). The treatment group after treatment indicators compared with the control group after treatment, the difference was significant (P <0.01). In the treatment group, nausea and vomiting occurred in 3 patients. Stool diarrhea occurred in 2 patients and the incidence of side effects was 5.7%. The control group had 5 cases of dry mouth; 3 cases of constipation, the incidence of side effects was 11.1%. All patients were not interrupted treatment, two side effects were compared, the difference was not statistically significant (P> 0.05). Conclusion: Weishu San-based triple therapy for the treatment of peptic ulcer with peptic ulcer combined with gastritis with good curative effect, less side effects, low cost, is a better program to eradicate Hp.