革兰阳性球菌与革兰阴性杆菌均能产生β内酰胺酶（βｌａｃｔａｍａｓｅｓ），作用于β内酰胺类抗生素，出现程度不同的耐药性，极大地威胁着临床使用。细菌产生耐药性的机制主要有三种类型：产生灭活酶；改变细菌胞浆膜通透性；改变靶位蛋白，而β内酰胺类抗生素... Gram-positive cocci and gram-negative bacilli are able to produce β  lactamase (β  lactamases), the role of β  lactam antibiotics, the emergence of different degrees of resistance, a great threat to clinical use. There are three main types of bacterial resistance mechanisms: the generation of inactivated enzymes; change the bacterial cytoplasmic membrane permeability; change the target protein, and β  lactam antibiotics ...