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培养Ｗｉｓｔａｒ大鼠乳鼠心室肌细胞，向培养基中分别加入浓度为５０μｇ／ｍＬ至８００μｇ／ｍＬ的刺五加叶皂甙单体（ＡｃａｎｔｈｏｐａｎａｘｓｅｎｔｉｃｏｓｉｄｅｓＣ１，Ｓｃ１），可使心肌细胞的自发性搏动呈剂量依赖性抑制，洗脱后能使之得以恢复。向培养基中加入１００μｇ／ｍＬＳｃ１，使培养的Ｗｉｓｔａｒ大鼠心肌细胞动作电位的波幅、波宽、阈电位、最大舒张电位、最大除极速度及复极（１０％、５０％、９０％）水平的动作电位波宽一致减小。Ｃａ２＋８０μｇ／ｍＬ能使之反转。Ｓｃ１作用与０．４μｇ／ｍＬ尼莫地平作用相似。上述结果表明Ｓｃ１具有钙通道阻滞作用。
The Wistar rat neonatal rat ventricular myocytes were cultured and Acanthopanax inicosides C1 and Sc1 were respectively added to the medium at a concentration of 50μg / mL to 800μg / mL. The spontaneous pulsation of cardiomyocytes in a dose-dependent manner Sexual inhibition, after elution can make it be restored. The amplitude, wave width, threshold potential, maximal diastolic potential, maximal depolarization rate and repolarization (10%, 50%, 90%) levels of action potential of cultured Wistar rats were increased by adding 100 μg / mL of Sc1 to the culture medium The action potential wave width decreases uniformly. Ca2 + 80μg / mL can make it reverse. The effect of Sc1 is similar to that of 0.4μg / mL nimodipine. The above results show that Sc1 has a calcium channel block.