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我们采用光化学方法诱发鼠实验性局灶性脑梗塞,观察了清栓酶的治疗作用,实验设正常对照组、脑梗塞未治疗组及清栓酶治疗组。实验结果显示清栓酶治疗组(0.25u/kg,Qd,iv,连用5天)自发性脑电活动明显改善;光镜与电镜观察发现病理变化明显减轻,病灶区出现明显胶质增生;血纤维蛋白原水平明显降低接近正常对照组;清栓酶治疗48小时,脑含水量测定平均为75.72±1.42％,较未治疗组(79.22±0.25％)明显减低(P<0.05)。这些结果提示于脑缺血后早期应用清栓酶,对脑自发性电活动,形态学改变及脑水肿的发生、发展均有明显改善作用。本研究表明清栓酶对缺血性脑梗塞有良好的治疗作用。
We used photochemical methods to induce experimental focal cerebral infarction in mice and observed the therapeutic effect of Qing thrombin. The experimental group was divided into normal control group, untreated group of cerebral infarction and Qingrease treatment group. The results showed that spontaneous electroencephalographic activity was significantly improved in the treated group (0.25u / kg, Qd, iv) for 5 days. The pathological changes were observed under light and electron microscopy, with obvious glial hyperplasia in the lesion area. The level of fibrinogen was significantly lower than that of the normal control group. After 48 hours of treatment, the average brain water content was 75.72 ± 1.42%, significantly lower than that of the untreated group (79.22 ± 0.25%, P <0.05). These results suggest that the early use of Qing-hua after cerebral ischemia, the brain spontaneous electrical activity, morphological changes and the occurrence and development of cerebral edema were significantly improved. This study shows that Qing thrombin has a good therapeutic effect on ischemic cerebral infarction.