在印度70年代开始流行黑热病的比哈尔邦,有30％的病人对葡萄糖酸锑钠治疗无效,这样高的无效可能是由于使用传统的10mg锑/kg/d,6～10天的疗程所用的药量不足所致。作者对4例经葡萄糖酸锑钠治疗无效的病人,给予该药30mg/kg/d,每天3次,间隔8小时进行治疗,结果有3例死于心力衰竭,1例无反应。死亡的3例心电图显示ST段下降,T波倒置。上述病人的血清谷丙转氨酶和 In Bihar, India, where epidemic kala-azar began in the 1970s, 30% of patients were ineffective with antimony gluconate, which may be due to the use of traditional 10 mg antimony / kg / day for 6 to 10 days Due to insufficient dose. The authors of 4 patients treated with antimony gluconate ineffective, given the drug 30mg / kg / d, 3 times a day, 8 hours apart for treatment, resulting in 3 cases died of heart failure, 1 case no response. Three cases of death showed ST-segment ECG decline, T wave inversion. Serum alanine aminotransferase and