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目的:探讨血浆脑钠肽(BNP)浓度对早发心绞痛患者近期心血管事件的预测价值。方法:检测110例早发心绞痛患者入院时的血浆BNP浓度,稳定型心绞痛(SAP)50例,不稳定型心绞痛(UAP)60例;26例健康体检者作为对照组。心绞痛患者按常规方法进行药物治疗和冠状动脉介入治疗,记录住院和随访平均6个月期间的心血管事件(心血管死亡、心力衰竭、再发心绞痛、心肌梗死);检测所有对象的BNP。结果:心绞痛组中UAP、SAP者与对照组血浆BNP浓度分别为(94.88±35.92)、(40.19±23.05)与(35.85±14.96)ng/L。UAP者平均BNP浓度高于SAP者和对照组(均P<0.01),SAP者与对照组BNP比较差异无统计学意义。UAP者心力衰竭、再发心绞痛、心肌梗死复合心血管事件发生率高于SAP者(20%∶6%,P<0.05)。SAP者、UAP者中发生心血管事件者BNP均高于未发生心血管事件者,分别为P<0.05、P<0.01。结论:血浆BNP浓度可以预测早发心绞痛患者近期心血管事件。
Objective: To investigate the predictive value of plasma brain natriuretic peptide (BNP) in recent cardiovascular events in patients with early-onset angina pectoris. Methods: Plasma BNP concentration, 50 cases of stable angina pectoris (SAP) and 60 cases of unstable angina pectoris (UAP) were detected in 110 patients with early-onset angina pectoris. Twenty-six healthy subjects were used as control group. Patients with angina pectoris were treated with drugs and coronary interventions according to conventional methods. Cardiovascular events (cardiovascular death, heart failure, recurrent angina pectoris and myocardial infarction) were recorded during hospitalization and follow-up on average for 6 months. BNP was measured in all subjects. Results: The plasma BNP concentrations in UAP, SAP and control group were (94.88 ± 35.92), (40.19 ± 23.05) and (35.85 ± 14.96) ng / L, respectively. The average BNP concentration in UAP patients was higher than that in SAP patients and controls (all P <0.01). There was no significant difference in BNP between SAP and control subjects. UAP heart failure, recurrent angina pectoris, myocardial infarction complicated cardiovascular events than SAP (20%: 6%, P <0.05). BNP in SAP and UAP patients with cardiovascular events were higher than those without cardiovascular events (P <0.05, P <0.01). Conclusions: Plasma BNP levels predict recent cardiovascular events in patients with early-onset angina.