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钾通道活化剂可激活钾离子通道并松驰支气管平滑肌，在急性分离的豚鼠支气管平滑肌细胞上，用膜片钳技术的细胞贴附式和内面向外式研究了其对电压依赖性钾通道的直接作用。结果证实：在全细胞记录条件下，卡吗克林和拉吗克林不影响静息膜电位。但在去极化时可使通道电导从７５．２±５．１ｐＳ分别增大到８５．９±１１．８ｐＳ和８２．１±５．５ｐＳ。通道动力学特性也发生了改变，通道平均开放时间的τｏ２值延长和开放概率显著增加，其中拉吗克林的作用更为强。两者均可诱发通道出现多级开放。表明这两类活化剂可使去极化时钾离子外流增加。
Potassium Channel Activators Activate Potassium Channels and Relax Bronchial Smooth Muscles The effect of voltage-dependent potassium channels on the acutely isolated guinea pig bronchial smooth muscle cells was investigated using patch-clamp technique in cell attachment and inwards-facing format Direct effect. The results confirm that caffeicin and lamamelin do not affect resting membrane potential under whole-cell recording conditions. However, the channel conductance was increased from 75.2 ± 5.1 pS to 85.9 ± 11.8 pS and 82.1 ± 5.5 pS respectively at depolarization. The kinetic properties of the channel also changed. The τo2 value of the average open time of the channel was prolonged and the probability of openness was significantly increased, and the effect of lamocapin was stronger. Both can induce multi-level opening of the channel. These two types of activators show that the depolarization can increase the outflow of potassium ions.