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为提高复合材料的力学性能和生物活性以聚己内酯(PCL)、壳聚糖(CS)、羟基磷灰石(HA)为原料,用Hakke流变仪挤出成型制备了不同HA含量的HA/PCL-CS复合材料,并对其进行了拉伸性能的测试,考察了复合材料浸渍于模拟体液(SBF)中的生物活性及其在生理盐水中的降解性能,用X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)、扫描电镜(SEM)、接触角测试仪对材料进行了表征。结果表明:复合材料的拉伸强度和断裂伸长率随HA含量的增加而降低,而杨氏模量随HA含量的增加而升高;亲水性能随着HA含量的增加而提高;HA/PCL-CS复合材料在模拟体液(SBF)中浸渍14 d后,在表面形成一层弱结晶的碳磷灰石(CHA)覆盖层,显示出良好的生物活性;PCL的分子量随着降解时间的延长而降低,溶液pH值和质量损失率却增大;浸渍28 d后,溶液pH值达到9.54,失重率达到5.86%,显示出良好的生物可降解性。
In order to improve the mechanical properties and biological activity of composites, polycaprolactone (PCL), chitosan (CS) and hydroxyapatite (HA) were used as raw materials, HA / PCL-CS composites were prepared and their tensile properties were tested. The biological activity of composites immersed in simulated body fluid (SBF) and their degradation in physiological saline were investigated. The effects of XRD ), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle tester. The results showed that the tensile strength and elongation at break of composites decreased with the increase of HA content, while the Young’s modulus increased with the increase of HA content. The hydrophilic property increased with the increase of HA content. The HA / PCL-CS composites showed a good bioactivity after immersing in SBF for 14 days, forming a weakly crystalline carbonated apatite (CHA) coating on the surface of PCL-CS composites. The molecular weight of PCL decreased with time Prolonged and decreased, the solution pH value and mass loss rate increased. After 28 d immersion, the pH value of the solution reached 9.54 and the weight loss rate reached 5.86%, showing good biodegradability.