呼吸道疾病的最新治疗方式,包括在机械通气时应用呼气末正压(PEEP)。此法即当病人呼气时,对其肺脏施加正压力;可用于自发呼吸或作机械通气的患者。PEEP的名称表明压力是治疗上的关键因素,实际上它造成静息期肺容量的改变。在改善氧合方面,PEEP的益处是十分清楚的,但也可能产生一些合并症。本文着重讨论PEEP对生理学的一些影响。对肺功能的影响由于呼气末透肺压增加,PEEP在呼气末可引起肺容量的增加,也就是说增加功能残气量(FRC)。肺疾病通常有FRC的降低,因为肺水肿、肺炎或其它病理过程每导致肺泡实变和/或肺泡萎陷。FRC降低往往是疾病最突出的 The latest treatment for respiratory diseases includes applying positive end expiratory pressure (PEEP) during mechanical ventilation. This method is when the patient exhales, exerting a positive pressure on his lungs; can be used for spontaneous breathing or mechanical ventilation in patients. The name of PEEP indicates that stress is a key therapeutic factor, and in fact it causes a change in lung volume at rest. The benefits of PEEP are very clear in improving oxygenation, but they may also cause some comorbidities. This article focuses on some of the effects of PEEP on physiology. Impact on Lung Function PEEP causes an increase in lung capacity at the end of expiration due to increased end-expiratory pulmonary pressure, which means increased functional residual capacity (FRC). Lung disease usually has a decrease in FRC, as pulmonary edema, pneumonia, or other pathological processes each cause alveolar consolidation and / or alveolar collapse. FRC is often the most prominent disease reduction